�Pregnant women who endure the psychological stress of being in a war zone ar more likely to establish birth to a small fry who develops schizophrenia. Research published in the opened access journal BMC Psychiatry supports a growing organic structure of literature that attributes maternal exposure to terrible stress during the early months of pregnancy to an increased susceptibility to schizophrenia in the offspring.
According to lead author Dolores Malaspina M.D., M.Sc.P.H., Anita Steckler and Joseph Steckler Professor of Psychiatry at the NYU School of Medicine. "The stresses in question are those that would be experienced in a natural disaster such as an earthquake or hurricane, a terrorist attack, or a sudden bereavement".
Data from 88,829 mass, born in Jerusalem from 1964 to 1976, were collected from the Jerusalem Perinatal Study that coupled birth records to Israel's Psychiatric Registry. The NYU authors discovered that the offspring of women wHO were in their instant month of pregnancy during the height of the Arab-Israeli war in June of 1967 (the "Six Day War") displayed a significantly higher incidence of schizophrenia all over the following 21-33 long time. The study also showed that the pattern was gender-specific, touching females more than males.
Following the 1967 war, females who had been in their second month of fetal life during the conflict were 4.3 times more than likely to develop dementia praecox than females born at other times. Males in their second month of fetal life were 1.2 multiplication more potential to develop schizophrenia. "It's a very striking confirmation of something that has been suspected for quite some clip", said Malaspina.
"The placenta is very sensitive to stress hormones in the mother," explains Malaspina, "these hormones were belike amplified during the time of the war."
The authors point proscribed that the study, which assessed ongoing medical records, only supports, rather than proves, the hypothesis that the sterling vulnerability to schizophrenia is in the second calendar month of maternity. Limitations to the study include a small sampling population as well as the absence of information on the exact length of gestation, which makes it possible that developmental stages were underestimated.
Malaspina also points out that pregnant women in general should not be alarmed about handling day-to-day stressors during pregnancy. "A developing foetus requires some exposure to maternal stress hormones as it normalizes their stress functioning," she says. "But women experiencing anxiety or excessive stress would do well to address it before a planned pregnancy and to have good social support systems."
About NYU Langone Medical Center
Located in the heart of New York City, NYU Langone Medical Center is one of the nation's chancellor centers of excellence in health care, biomedical research, and medical education. For over 167 years, NYU physicians and researchers have made myriad contributions to the practice and scientific discipline of health care. Today the Medical Center consists of NYU School of Medicine, including the Smilow Research Center, the Skirball Institute of Biomolecular Medicine, and the Sackler Institute of Graduate Biomedical Sciences; the trey hospitals of NYU Hospitals Center, Tisch Hospital, a 726-bed acute-care general infirmary, Rusk Institute of Rehabilitation Medicine, the first and largest facility of its kind, and NYU Hospital for Joint Diseases, a leader in musculoskeletal forethought; and such major programs as the NYU Cancer Institute, the NYU Child Study Center, and the Hassenfeld Children's Center for Cancer and Blood Disorders.
1. Acute maternal stress in pregnancy and schizophrenia in offspring: a cohort prospective study.
D Malaspina, C Corcoran, K R Kleinhaus, M C Perrin, S Fennig, D Nahon, Y Friedlander and S Harlap
BMC Psychiatry
2. The co-authors of this study are: Cheryl Corcoran, Karine R Kleinhaus, Mary C Perrin, Shmuel Fennig, Daniella Nahon and Yechiel Friedlander. The study was supported by grants from the National Institutes of Health: and from the National Alliance for Research of Schizophrenia and Depression (NARSAD).
3. BMC Psychiatry is an candid access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of psychiatrical disorders, as well as related molecular genetics, pathophysiology, and epidemiology. BMC Psychiatry (ISSN 1471-244X) is indexed/tracked/covered by PubMed, MEDLINE, CAS, Scopus, EMBASE, Thomson Scientific (ISI) and Google Scholar.
4. BioMed Central (http://www.biomedcentral.com/) is an independent online publishing house committed to providing immediate access without charge to the peer-reviewed biological and medical research it publishes. This loyalty is based on the view that open entree to research is essential to the rapid and efficient communication of science.
Source: Nadine Woloshin
NYU Langone Medical Center / New York University School of Medicine
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Monday, 25 August 2008
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